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N Upton Selected Research

tonabersat

4/2001Tonabersat (SB-220453) a novel benzopyran with anticonvulsant properties attenuates trigeminal nerve-induced neurovascular reflexes.
7/2000Repetitive cortical spreading depression in a gyrencephalic feline brain: inhibition by the novel benzoylamino-benzopyran SB-220453.
7/2000The potential anti-migraine compound SB-220453 does not contract human isolated blood vessels or myocardium; a comparison with sumatriptan.
3/2000SB-220453, a potential novel antimigraine agent, inhibits nitric oxide release following induction of cortical spreading depression in the anaesthetized cat.

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N Upton Research Topics

Disease

4Migraine Disorders (Migraine)
02/2001 - 03/2000
3Pain (Aches)
11/2021 - 06/2001
3Hyperalgesia
11/2021 - 05/2001
3Hyperphagia (Overeating)
11/2005 - 01/2001
2Narcolepsy
05/2009 - 05/2002
2Weight Gain
05/2005 - 02/2005
2Weight Loss (Weight Reduction)
02/2005 - 03/2004
2Anorexia
02/2005 - 03/2004
2Hippocampal Sclerosis
01/2001 - 01/2001
2Temporal Lobe Epilepsy
01/2001 - 01/2001
1Femoral Fractures (Femoral Fracture)
11/2021
1Syringomyelia (Morvan's Disease)
08/2019
1Neuralgia (Stump Neuralgia)
08/2019
1Asthma (Bronchial Asthma)
10/2015
1Hypersensitivity (Allergy)
10/2015
1Central Nervous System Diseases (CNS Diseases)
05/2009
1Parkinson Disease (Parkinson's Disease)
05/2008
1Body Weight (Weight, Body)
11/2005
1Obesity
11/2005
1Nausea
05/2005
1Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome)
05/2002
1Generalized Epilepsy
06/2001
1Epilepsy (Aura)
06/2001
1Nervous System Diseases (Neurological Disorders)
06/2001
1Substance-Related Disorders (Drug Abuse)
06/2001
1Polydipsia
05/2001
1Ganglion Cysts (Ganglion)
04/2001
1Seizures (Absence Seizure)
11/2000
1Neurogenic Inflammation
07/2000
1Stroke (Strokes)
03/2000
1Traumatic Brain Injuries (Traumatic Brain Injury)
03/2000
1Inflammation (Inflammations)
03/2000

Drug/Important Bio-Agent (IBA)

5OrexinsIBA
11/2005 - 01/2001
41- (2- methylbenzoxazol- 6- yl)- 3- (1,5)naphthyridin- 4- yl ureaIBA
11/2005 - 03/2004
4GABA-B ReceptorsIBA
06/2001 - 11/2000
4tonabersatIBA
04/2001 - 03/2000
3gamma-Aminobutyric Acid (GABA)IBA
06/2001 - 11/2000
3Nitric Oxide (Nitrogen Monoxide)FDA Link
02/2001 - 03/2000
2Appetite Depressants (Anorectics)IBA
05/2005 - 02/2005
2Messenger RNA (mRNA)IBA
01/2001 - 11/2000
1Nerve Growth Factor (NGF)IBA
11/2021
1salicylhydroxamic acid (SHAM)IBA
11/2021
1Pregabalin (Lyrica)FDA Link
08/2019
1Analgesics (Analgesic Drugs)IBA
08/2019
1Immunoglobulin E (IgE)IBA
10/2015
1Histamine H3 AntagonistsIBA
05/2009
1PPAR gammaIBA
05/2008
1Monoamine Oxidase (MAO)IBA
05/2008
1Pioglitazone (Actos)FDA Link
05/2008
11- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
05/2008
1Orexin ReceptorsIBA
05/2002
1GABA-B Receptor AntagonistsIBA
06/2001
1Pharmaceutical PreparationsIBA
05/2001
1Morphine (MS Contin)FDA LinkGeneric
05/2001
1Clozapine (Clozaril)FDA LinkGeneric
05/2001
1CarrageenanIBA
05/2001
1Diazepam (Valium)FDA LinkGeneric
05/2001
1Gabapentin (Neurontin)FDA LinkGeneric
04/2001
1Lamotrigine (Lamictal)FDA LinkGeneric
04/2001
1OligonucleotidesIBA
11/2000
1Proteins (Proteins, Gene)FDA Link
11/2000
1BenzopyransIBA
07/2000
1Sumatriptan (Imigran)FDA LinkGeneric
07/2000
1ConvulsantsIBA
07/2000

Therapy/Procedure

1Therapeutics
11/2021
1External Fixators
11/2021